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Effects of Alcoholism and Continued Abstinence on Brain Volumes in Both Genders

Dienstag 24. Mai 2011 von htm

Background:  Alcohol abuse has detrimental effects on cerebral function, metabolism, and volume. Some of these effects were found to be at least partially reversible with continued abstinence. Furthermore, it has been reported that there are different effects of alcohol on brain volumes for women compared with men, but the results concerning the interaction between alcohol dependence and gender are inconsistent. …
Results:  Global cerebrospinal fluid (CSF) volume was increased and WM and GM volume decreased equally in male and female patients. A gender by diagnosis interaction was found neither for global nor for regional volumes or VBM data. VBM whole brain analysis yielded a significant GM volume loss in the patient group in the cingulate gyrus and the insula in both hemispheres. Region of interest analysis for the initial and 3 months follow-up scans yielded significant gains in regional volumes, particularly the cingulate gyrus and the insula in the group of abstinent patients, whereas no volume change at all is found in the patients who had relapsed.
Conclusions:  Our study confirms widespread cerebral volume loss in recently detoxified alcoholics. The effects of alcohol dependence seem to have equally adverse effects on brain morphometry in males and females. (Source: Alcohol Reports, 5/23/11) onlinelibrary.wiley.com, 5/20/11

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Dieser Beitrag wurde erstellt am Dienstag 24. Mai 2011 um 13:50 und abgelegt unter Addiction, adults, Allgemein, Gender, Global, Health, Research, Treatment. Kommentare zu diesen Eintrag im RSS 2.0 Feed. Die Kommentare sind derzeit geschlossen, aber sie können einen Trackback auf Ihrer Seite einrichten.

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