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Research: Alcohol Consumption at Midlife and Risk of Stroke

Donnerstag 5. Februar 2015 von htm

Original Contribution
Alcohol Consumption at Midlife and Risk of Stroke During 43 Years of Follow-Up
Cohort and Twin Analyses
Pavla Kadlecová, MSc,
Ross Andel, PhD,
Robert Mikulík, PhD,
Elizabeth P. Handing, BA and
Nancy L. Pedersen, PhD
STROKE AHA.114.006724
Published online before print January 29, 2015, doi: 10.1161/STROKEAHA.114.006724

From the International Clinical Research Center, Neurology Department, St. Anne’s Hospital, Brno, Czech Republic (P.K., R.A., R.M.); School of Aging Studies, University of South Florida, Tampa (R.A., E.P.H.); Department of Neurology, St. Anne’s University Hospital and Medical Faculty of Masaryk University, Brno, Czech Republic (R.M.); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (N.L.P.); and Department of Psychology, University of Southern California, Los Angeles (N.L.P.).
Correspondence to Pavla Kadlecová, MSc, Pekařská 53, 656 91 Brno, Czech Republic. E-mail kadlecovap{at}fnusa.cz

Abstract

Background and Purpose—Although alcohol–stroke association is well known, the age-varying effect of alcohol drinking at midlife on subsequent stroke risk across older adulthood has not been examined. The effect of genetic/early-life factors is also unknown. We used cohort and twin analyses of data with 43 years of follow-up for stroke incidence to help address these gaps.

Methods—All 11 644 members of the population-based Swedish Twin Registry born 1886 to 1925 with alcohol data aged ≤60 years were included. The interaction of midlife alcohol consumption by age at stroke was evaluated in Cox-regression and analyses of monozygotic twins were used. Covariates were baseline age, sex, cardiovascular diseases, diabetes mellitus, stress reactivity, depression, body mass index, smoking, and exercise.

Results—Altogether 29% participants developed stroke. Compared with very-light drinkers (<0.5 drink/d), heavy drinkers (>2 drinks/d) had greater risk of stroke (hazard ratio, 1.34; P=0.02) and the effect for nondrinkers approached significance (hazard ratio, 1.11; P=0.08). Age increased stroke risk for nondrinkers (P=0.012) and decreased it for heavy drinkers (P=0.040). Midlife heavy drinkers were at high risk from baseline until the age of 75 years when hypertension and diabetes mellitus grew to being the more relevant risk factors. In analyses of monozygotic twin-pairs, heavy drinking shortened time to stroke by 5 years (P=0.04).

Conclusions—Stroke-risk associated with heavy drinking (>2 drinks/d) in midlife seems to predominate over well-known risk factors, hypertension and diabetes, until the age of ≈75 years and may shorten time to stroke by 5 years above and beyond covariates and genetic/early-life factors. Alcohol consumption should be considered an age-varying risk factor for stroke.

Kategorie: adults, Allgemein, consumption, Education, English Website, Global, Health, mortality, Non-communicable diseases, Research, Statistics | Keine Kommentare »

Eurocare_Press_Release re World Cancer Day (4th of Febr.)

Donnerstag 5. Februar 2015 von htm

Eurocare_Press_Release_Alcohol_can_cause_cancer

_limit_your_intake_4th_Feb_2015

Kategorie: Alerts, Allgemein, consumption, drinking guidelines, English Website, Events, Health, morbidity, mortality, Non-communicable diseases, Publications, safe level, WHO | Keine Kommentare »

Jetzt ist definitiv Schluss / Now this is the end of this website

Freitag 31. August 2012 von htm

After 10 years of full and one year with reduced activity this website is only working as an archive.

Nach 10 Jahren mit voller und einem Jahr mit reduzierter Aktivität wird diese Website zum Archiv.

Thanks to all readers who have profited from its content. Thanks also to all friends and public health specialists who have contributed to form and content.

Herzlichen Dank allen Leserinnen und Lesern, die den Inhalt nutzbringend verwendet haben. Vielen Dank auch allen Sympathisanten, FreundInnen und Fachleuten, die zu Form und Inhalt beigetragen haben.

It has been a fantastic task and a big challenge which gave me much satisfaction.

Es war eine fantastische Aufgabe und eine grosse Herausforderung, die mir Freude und Anerkennung gebracht hat. Alle, die durch meine Arbeitsbelastung zu kurz gekommen sind, bitte ich um Nachsicht.

Good bye, all the best!                Auf Wiedersehen und alles Gute!

Ausnahme:
Meine Leserbriefe werde ich weiterhin hier zeigen und archivieren.

************************************************************************************

Kategorie: Global, Health, Schweiz, Veröffentlichungen | Keine Kommentare »

UK: Alcohol Awareness Week 2012: 19-25 November “It’s time to talk about drinking”

Montag 13. August 2012 von htm

Alcohol Concern, the national charity for alcohol misuse, have announced Alcohol Awareness Week (AAW) 2012 on the theme of “It’s time to talk about drinking”.

Alcohol Concern hopes it will help trigger all kinds of conversations about the health risks, social problems, stigmas and taboos associated with talking about the dangers of Hair of the dog alcohol. A set of conversation starter cards are available to download.

The release also states:

‘One of the main ways we are going to start the conversation is by challenging people to give up alcohol for a month in January. From AAW people will be able to sign up either as an individual or a team to give up drinking for a month. We’re going to ask people to pledge money or get sponsored to motivate them to stick at the challenge. We’ll also be providing people with tips and information on cutting down and how this will help their health, sleeping patterns and general wellbeing.’ …
(Source: Alcohol Policy UK, 08/12/12)
Comment: The theme “Let’s talk about alcohol” for an alcohol awareness week in Switzerland was misused in some places by talking about how normal it is to drink.

Kategorie: Allgemein, consumption, Events, Global, Health, Prevention, Watchdogs | Keine Kommentare »

A Prospective Cohort Study of the Prevalence of Growth, Facial, and Central Nervous System Abnormalities in Children with Heavy Prenatal Alcohol Expos

Donnerstag 26. Juli 2012 von htm

Most children who are exposed to large quantities of alcohol in utero do not develop fetal alcohol syndrome (FAS). Population-based prospective data on the risk of developing components of fetal alcohol spectrum disorders (FASD), however, are limited.

This was a prospective cohort study of 9,628 women screened during their first prenatal appointment in Chile, which identified 101 who consumed at least 4 drinks/d (exposed) matched with 101 women with no reported alcohol consumption during pregnancy (unexposed). Detailed alcohol consumption data were collected during the pregnancy. Children were evaluated up to 8.5 years of age by clinicians masked to exposure status. …

After exposure to heavy alcohol consumption during pregnancy, 80% of children had 1 or more abnormalities associated with alcohol exposure. Patterns of alcohol use that posed the greatest risk of adverse outcomes were binge drinking and high total weekly intake. Functional neurologic impairment occurred most frequently and may be the only sign to alert physicians to prenatal alcohol exposure. ….
(Source: Alcohol Reports, 07/23/12) onlinelibrary.wiley.com, 07/23/12

Kategorie: adults, Allgemein, Binge Drinking, Children, consumption, Fetal alcohol syndrome etc., Gender, Global, Health, Parents, Research | Keine Kommentare »

Alcohol Harms Thinking in Older Adults, Researchers Say

Donnerstag 26. Juli 2012 von htm

Certain types of alcohol use after age 65 may affect memory and thinking, according to two studies that raise new questions about earlier research that suggested drinking may stymie cognitive decline.

People 65 and older who regularly consumed four or more alcoholic beverages at a time, a situation described in the study as binge-drinking, were more likely to have the highest drop-off in brain function and the most memory decline, according to one result. A second study reported that women who indulged heavily early in life or were moderate drinkers after 65 were more likely to have cognitive impairment.

Drinking alcohol had been thought to reduce the risk of cognitive decline in some older people, the Alzheimer’s Association said in a statement. Today’s reports, presented at the Alzheimer’s Association International Conference in Vancouver, suggest more research is needed. …
(Source: Alcohol Reports, 07/25/12) businessweek.com, 07/18/12

Kategorie: Allgemein, Binge Drinking, consumption, Global, Health, morbidity, Research, Research-Fraud, Seniors | Keine Kommentare »

Drinking alcohol, even in moderation, ‘a dementia risk’

Mittwoch 18. Juli 2012 von htm

The findings, presented at an international conference, challenge the notion that some alcohol could be good for ageing brains.

People who stick to recommended alcohol limits are still at risk, as well as bingers and heavy drinkers, according to the work.

The study tracked the health over 20 years of 1,300 women in their mid-60s.

The risk, ranging from mild cognitive impairment to full blown dementia, was higher among those who reported drinking more alcohol.

Women who switched from abstinence to drinking over the course of the study also increased their risk.

Those who drank alcohol “in moderation”, meaning seven to 14 alcoholic drinks a week, were also more likely to develop problems with memory and brain functioning that can be a warning sign of future dementia. …
(Source: Google alcohol news, 07/18/12) (news-ad-hoc.de, 18.7.12) bbc.co.uk, 07/18/12

Kategorie: adults, Allgemein, Binge Drinking, consumption, drinking guidelines, Gender, Global, Health, morbidity, Publications, Research, safe level, Statistics | Keine Kommentare »

Some People Suffer Allergy-Like Symptoms After Drinking Wine

Sonntag 8. Juli 2012 von htm

Around seven percent of adults suffer from an intolerance to wine. This is the result of a survey presented by Peter Wigand and co-authors in the current edition of Deutsches Arzteblatt International (Dtsch Arztebl Int 2012; 109 (25): 437-44).

The authors evaluated 948 questionnaires that were returned from the 4000 sent out to randomly selected people between the ages of 20 and 69 years. They found that women (8.9%) were more often affected by an intolerance to wine than men (5.2%). The most commonly reported reactions included flushed and itchy skin and a runny nose. The symptoms were particularly common after drinking red wine. Additionally, people with a wine intolerance were more likely to report other food intolerances. …
(Source: Medical News Today, 7/7/12)

Kategorie: Allgemein, consumption, Global, Health, Research, Statistics | Keine Kommentare »

Eurocare warns of alcohol-related cancer risks

Montag 2. Juli 2012 von htm

The European Alcohol Policy Alliance has launched a new website to flag up the risks associated with alcohol consumption and cancer.

Alcohol is a carcinogenic (cancer causing) substance, yet only 1 in 5 people are aware of the risks that alcohol can bring. 10% of the total cancers in males and 3% of the total cancers in females are thought to be associated with alcohol consumption. A range of cancers are linked to alcohol, including liver cancer and prostate cancer. Any alcohol can increase the risk, so there isn’t a “safer” alcoholic drink to gravitate to. …
(Source: Eurocare, 07/02/12)

Kategorie: Allgemein, consumption, Documents, drinking guidelines, Global, Health, Media, morbidity, mortality, Non-communicable diseases, Prevention, Publications, Research, Statistics, Watchdogs | Keine Kommentare »

USA: Pennsylvania Alcohol Privatization Off the Table

Donnerstag 28. Juni 2012 von htm

State Control of Alcohol: Protecting the Public’s Health

Pennsylvania Republican House Majority Leader Michael Turzai recently gave up the fight to privatize liquor sales in the state, at least for the moment. The battle to privatize Pennsylvania’s 620 state-owned liquor and wine stores, and to allow the sale of alcohol by non-state retailers, has been raging in Pennsylvania for several years. In 2010, then-gubernatorial candidate (now governor) Tom Corbett made alcohol privatization a key part of his election campaign. Since then, advocates for state control and new research findings regarding its effectiveness have helped fight off the ill-fated plan.

When the 21st Amendment repealed national prohibition in 1933, states became responsible for
regulating alcoholic beverages. While many states decided to license private businesses to sell alcohol,
18 states chose to control alcohol sales themselves. The goal was to provide a legal way for people
to obtain alcohol, but also encourage moderate consumption by reducing economic incentives for
maximum sales.

States that currently have monopolies over control either beer, wine, or spirits (or some combination)
are: Alabama, Idaho, Iowa, Maine, Michigan, Mississippi, Montana, New Hampshire, North Carolina,
Ohio, Oregon, Pennsylvania, Utah, Vermont, Virginia, Washington, West Virginia, and Wyoming. In
addition, Montgomery County, Maryland controls spirits, beer, and wine (the only jurisdiction that
controls all three). …
(Source: Alcohol Justice, 06/27/12)

Kategorie: Addiction, adults, Alcohol industry, Alcohol taxes, Allgemein, Availability, consumption, Driving under the Influence, Global, Health, mortality, Parliaments / Governments, Politics, Prevention, Research, societal effects, Statistics, Watchdogs, Youth | Keine Kommentare »

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